Deoxygenation-Induced Cation Fluxes in Sickle Cells: 11. Inhibition by Stilbene Disulfonates
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منابع مشابه
Deoxygenation-induced cation fluxes in sickle cells: II. Inhibition by stilbene disulfonates.
Deoxygenation-induced cation movements in sickle cells were inhibited 80% to 85% by the anion transport inhibitor, 4,4'-diisothiocyano-2,2'disulfostilbene (DIDS). Morphologic sickling was not altered by DIDS treatment, demonstrating that morphologic sickling was not sufficient to produce cation leaks in sickle cells. DIDS inhibition of deoxygenation-induced cation flux was not affected when l- ...
متن کاملDeoxygenation-Induced Cation Fluxes in Sickle Cells: 11. Inhibition by Stilbene Disulfonates
Deoxygenation-induced cation movements in sickle cells were inhibited 80% to 85% by the anion transport inhibitor, 4,4’-diisothiocyano-2,2’disulfostilbene (DIDS). Morphologic sickling was not altered by DlDS treatment, demonstrating that morphologic sickling was not sufficient to produce cation leaks in sickle cells. DlDS inhibition of deoxygenationinduced cation flux was not affected when Irep...
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We hypothesized that the deoxygenation-induced increase in cation permeability of sickle cells was related to mechanical distention of the membrane by growing HbS polymer within the cell. To test this hypothesis, we determined the effect of deoxygenation on cation fluxes in sickle cells under conditions that restricted or permitted extensive growth of polymer, producing different degrees of mem...
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Sickling-induced cation fluxes contribute to cellular dehydration of sickle red blood cells (SS RBCs), which in turn potentiates sickling. This study examined the inhibition by dipyridamole of the sickling-induced fluxes of Na(+), K(+), and Ca(++) in vitro. At 2% hematocrit, 10 microM dipyridamole inhibited 65% of the increase in net fluxes of Na(+) and K(+) produced by deoxygenation of SS RBCs...
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Sickling-induced cation fluxes contribute to cellular dehydration of sickle red blood cells (SS RBCs), which in turn potentiates sickling. This study examined the inhibition by dipyridamole of the sicklinginduced fluxes of Na1, K1, and Ca11 in vitro. At 2% hematocrit, 10 mM dipyridamole inhibited 65% of the increase in net fluxes of Na1 and K1 produced by deoxygenation of SS RBCs. Sickle-induce...
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